Results suggest that berberine combined metformin or combined glipizide had a better effect than metformin or glipizide in the treatment of type 2 diabetes and berberine may decrease the leves of TG and TC. The meta-analysis of 10 included randomized clinical trials (RCTs),included 621 patients ,showed :There were significantly differences between berberine combined metformin or combined glipizide groups and metformin or glipizide groups in the total efficacy of lowering blood glucose and/or reguleting blood lipids (P0.05) There were significantly differences between berberine groups and metformin, glipizide or placebo groups in lowering HbA1c ,TG and TC (P0.05) While there were no differences between the berberine groups and metformin, glipizide or palcebo groups in decreasing FBG and 2hPBG (P0.05) There were no differences between the berberine groups and metformin, glipizide or palcebo groups in decreasing LDL-C and increasing HDL-C (P0.05).
Berberine (BBR) is a classical natural medicine. TCM treatment has certain advantages of less toxicity and/or side effects, and herbs could provide multiple therapeutic effects. Two authors of us independently extracted datas and assessed the trials quality.Meta-analysis was conducted with RevMan 5.0 software. Traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of diabetes mellitus (DM). The hypoglycemic effect of berberine was similar to that of metformin. In study A, 36 adults with newly diagnosed type 2 diabetes were randomly assigned to treatment with berberine or metformin (0.5 g t.i.d.) in a 3-month trial. Systematic Review on Berberine in the Treatment of Type 2 Diabetes To assess the efficacy and saf To assess the efficacy and safety of berberine (an isoquinoline alkaloid) in the treatment of type 2 diabetes we searched electronic databases including PubMed (19782010), Medline (19962010), Excerpta Medica Database (19742010), Cochrane library, Chinese Biomedical Literature Database (19782010), the Chinese Scientific and Technical Journals database (19892010) and Chinese National Knowledge Infrastructure databases (19942010) and selected randomized clinical trials (RCTs) of berberine in the treatment of type 2 diabetes. This pilot study was to determine the efficacy and safety of berberine in the treatment of type 2 diabetic patients.
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